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In this study, intracellular ROS induced lipid peroxidation, leading to phospholipid structural damage and loss of membrane integrity, which in turn triggered iron-dependent cell death

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Furthermore, we discovered that the cytotoxicity of BSO is reduced following iNOS knockdown

Analysis of the differentially abundant metabolites revealed that globomycin abundance was increased in prediabetes, and that of 11 metabolites, such as ethylglyoxalbis (guanylhydrazone), molybdopterin guanine dinucleotide, octyl alpha-D-glucopyranoside, citicoline, 7alpha-hydroxy-5beta-cholestan-3-one, ProAla Val, and prodigiosin, was decreased after treatment with liraglutide